Rosenthal, zinc late treatment study: 16% higher mortality [p=0.003] https://c19p.org/rosenthalz
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Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19
et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.29058
Retrospective database analysis of 64,781 hospitalized patients in the USA, showing lower mortality with vitamin C or vitamin D (authors do not distinguish between the two), and higher mortality with zinc and HCQ, statistically significant for zinc. Authors excluded hospital-based outpatient visits, without explanation. Confounding by indication is likely, adjustments do not appear to include any information on COVID-19 severity at baseline.
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risk of death, 16.0% higher, OR 1.16, p = 0.003, adjusted per study, multivariable, RR approximated with OR.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
This study is excluded in the after exclusion results of meta
analysis:
confounding by indication is likely and adjustments do not consider COVID-19 severity at baseline.
Rosenthal et al., 12/10/2020, retrospective, database analysis, USA, North America, peer-reviewed, 5 authors.
Late treatment
is less effective
is less effective
rosenthal
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