COVID-19 studies for: C19 studies:  HC QHC Q IvermectinIVM Vitamin DVitamin D ZincZn REGN-COV2REGN LY-CoVLY RemdesivirRMD
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10/26
Positive
POSITIVE
Late
Frontera et al., Research Square, doi:10.21203/rs.3.rs-94509/v1 (Preprint)
death, ↓37.0%, p=0.01 Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study
Retrospective 3,473 hospitalized patients showing 37% lower mortality with HC Q+zinc. PSM aHR 0.63, p=0.015 regression aHR 0.76, p = 0.023
10/26
Positive
POSITIVE
PrEP
Berrocal et al., Research Square, doi:10.21203/rs.3.rs-95524/v1 (Preprint)
death, ↓44.8%, p=0.23 Zinc and Vitamin a Deficiency Predisposes to the Need for Intubation and Icu Admission in Patients With COVID-19. An Observational Study
Retrospective 120 hospitalized patients showing zinc deficiency associated with a higher ICU admission rate (61.8% vs.29%; p = 0.002) and a higher rate of intubation (87.5% vs. 12.5%; p = 0.002).
10/26
Positive
POSITIVE
Early
Derwand et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106214 (preprint 7/3) (Peer Reviewed)
death, ↓79.4%, p=0.12 COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxych loroquine and Azithromycin: A Retrospective Case Series Study
79% lower mortality and 82% lower hospitalization with early HC Q+AZ+Z. Retrospective 518 patients (141 treated, 377 control).
10/20
Positive
POSITIVE
PrEP
Heller et al., Redox Biology, doi:10.1016/j.redox.2020.101764 (Peer Reviewed)
Prediction of Survival Odds in COVID-19 by Zinc, Age and Selenoprotein P as Composite Biomarker
Analysis of 35 COVID-19 patients showing a significant correlation for serum zinc levels between COVID-19 patients and controls, and between COVID-19 survivors and non-survivors.
10/11
Positive
POSITIVE
Late
Vogel-González et al., medRxiv, doi:10.1101/2020.10.07.20208645 (Preprint)
Low zinc levels at clinical admission associates with poor outcomes in COVID-19
Shows a correlation between serum zinc levels and COVID-19 outcome. Almost all patients received HC Q.
5/8
Positive
POSITIVE
Late
Carlucci et al., J. Med. Microbiol., Sep 15, 2020, doi: 10.1099/jmm.0.001250 (preprint 5/8) (Peer Reviewed)
death/hospice, ↓37.8%, p=0.002 Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients
Retrospective 932 patients. Addition of Zinc to HC Q+AZ reduces mortality / transfer to hospice, ICU admission, and the need for ventilation. Reduction in mortality or transfer to hospice adjusted odds ratio OR 0.56..
2010
In Vitro
IN VITRO
In Vitro
te Velthuis et al., PLOS Pathogens 2010, 6:11, doi:10.1371/journal.ppat.1001176 (Peer Reviewed) (In Vitro)
Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
Shows that the combination of Zn2+ and a zinc ionophore (pyrithione) at low concentrations inhibits the replication of SARS-CoV and equine arteritis virus (EAV) in cell culture. Recommends further study of the use of zinc-ionophores as an..


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