Kaplan, 30 patient zinc late treatment RCT: 14% higher ventilation [p=1], 14% higher ICU admission [p=1], and 14% higher hospitalization [p=1] https://c19p.org/kaplan
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Resveratrol and Zinc in the Treatment of Outpatients With COVID-19 – The Reszinate Study - A Phase 1/2 Randomized Clinical Trial Utilizing Home Patient-Obtained Nasal and Saliva Viral Sampling
et al., SSRN, 10.2139/ssrn.3934228 (Preprint)
Small RCT of zinc plus resveratrol in COVID-19+ outpatients, showing no significant differences in viral clearance or symptoms. Although the treatment group was older (46.3 vs. 38.5) and had more severe baseline symptoms, they had similar symptomatic recovery by the second week.
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risk of mechanical ventilation, 14.3% higher, RR 1.14, p = 1.00, treatment 1 of 14 (7.1%), control 1 of 16 (6.2%).
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risk of ICU admission, 14.3% higher, RR 1.14, p = 1.00, treatment 1 of 14 (7.1%), control 1 of 16 (6.2%).
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risk of hospitalization, 14.3% higher, RR 1.14, p = 1.00, treatment 1 of 14 (7.1%), control 1 of 16 (6.2%).
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Kaplan et al., 1 Oct 2021, Randomized Controlled Trial, USA, preprint, 12 authors, study period 21 September, 2020 - 22 January, 2021, average treatment delay 5.9 days, this trial uses multiple treatments in the treatment arm (combined with resveratrol) - results of individual treatments may vary.
Late treatment
is less effective
is less effective
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