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Zinc study #5   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mechanical ventilation 92% Imp. Relative Risk, 95% CI Yasui: Analysis of the predictive factors for a critical illnes.. c19zinc.com/yasui.html Favors zinc Favors control
9/7 Analysis of outcomes based on serum levels
Yasui et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.09.008 (Peer Reviewed)
Analysis of the predictive factors for a critical illness of COVID-19 during treatment - relationship between serum zinc level and critical illness of COVID-19
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Retrospective 62 hospitalized patients, 29 with serum zinc data, showing significantly lower serum zinc levels for severe COVID-19 cases (intubation) compared with mild and moderate cases, p = 0.005. Authors recommend zinc supplementation.
risk of mechanical ventilation, 92.5% lower, RR 0.08, p = 0.001, high zinc levels 1 of 20 (5.0%), low zinc levels 6 of 9 (66.7%), zinc >= 70μg/dL.
Yasui et al., 9/7/2020, retrospective, Japan, Asia, peer-reviewed, 10 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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