The Minimal Effect of Zinc on the Survival of Hospitalized Patients With COVID-19

7/22 Late treatment study

Yao et al., Chest, doi:10.1016/j.chest.2020.06.082 (Peer Reviewed)
The Minimal Effect of Zinc on the Survival of Hospitalized Patients With COVID-19

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Retrospective 242 hospitalized patients in the USA showing adjusted hazard ratio for zinc treatment, aHR 0.66 [0.41-1.07]. [1] notes that the study would be more informative if baseline serum zinc levels were known.

Yao et al., 7/22/2020, retrospective, USA, North America, peer-reviewed, 9 authors.

risk of death, 34.0% lower, RR 0.66, p = 0.09, treatment 73 of 196 (37.2%), control 21 of 46 (45.7%), adjusted per study, multivariate Cox regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

[1] ncbi.nlm.nih.gov/pmc/articles/PMC7836617/

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