10/11 Analysis of outcomes based on serum levels
et al., Nutrients, doi:10.3390/nu13020562 (preprint 10/11/2020) (Peer Reviewed)
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection
Retrospective 249 PCR+ hospitalized patients in Spain, 58 with zinc levels on admission <50 μg/dL, showing higher mortality and ICU admission, and slower recovery with low zinc levels.
Vogel-González et al., 10/11/2020, retrospective, Spain, Europe, peer-reviewed, 16 authors.
risk of death, 77.2% lower, RR 0.23, p < 0.001, high zinc levels 9 of 191 (4.7%), low zinc levels 12 of 58 (20.7%), ≥50 μg/dL.
risk of ICU admission, 71.3% lower, RR 0.29, p < 0.001, high zinc levels 34 of 191 (17.8%), low zinc levels 36 of 58 (62.1%), ≥50 μg/dL.
recovery time, 68.0% lower, relative time 0.32, p < 0.001, high zinc levels 191, low zinc levels 58, ≥50 μg/dL.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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