Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

10/11 Analysis of outcomes based on serum levels

Vogel-González et al., Nutrients, doi:10.3390/nu13020562 (preprint 10/11/2020) (Peer Reviewed)
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

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Retrospective 249 PCR+ hospitalized patients in Spain, 58 with zinc levels on admission <50 μg/dL, showing higher mortality and ICU admission, and slower recovery with low zinc levels.

Vogel-González et al., 10/11/2020, retrospective, Spain, Europe, peer-reviewed, 16 authors.

risk of death, 77.2% lower, RR 0.23, p < 0.001, treatment 9 of 191 (4.7%), control 12 of 58 (20.7%), ≥50 μg/dL.

risk of ICU admission, 71.3% lower, RR 0.29, p < 0.001, treatment 34 of 191 (17.8%), control 36 of 58 (62.1%), ≥50 μg/dL.

recovery time, 68.0% lower, relative time 0.32, p < 0.001, treatment 191, control 58, ≥50 μg/dL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 31 studies All Outcomes

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