Retrospective 120 hospitalized patients in Spain showing zinc deficiency associated with higher ICU admission.
Tomasa-Irriguible et al., 10/26/2020, retrospective, Spain, Europe, peer-reviewed, 7 authors.
risk of mechanical ventilation, 49.3% lower, RR 0.51, p = 0.06, high zinc levels 7 of 31 (22.6%), low zinc levels 49 of 89 (55.1%), adjusted per study, odds ratio converted to relative risk, ≥84 mcg/dL, multivariate logistic regression.
risk of ICU admission, 52.0% lower, RR 0.48, p = 0.02, high zinc levels 9 of 31 (29.0%), low zinc levels 55 of 89 (61.8%), adjusted per study, odds ratio converted to relative risk, ≥84 mcg/dL, multivariate logistic regression, final model.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.