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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mechanical ventilation 49% Improvement Relative Risk ICU admission 52% c19zinc.com/tomasairriguiblez.html Favors zinc Favors control
26 October 2020 - Analysis of outcomes based on serum levels
Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave
Tomasa-Irriguible et al., Metabolites, doi:10.3390/metabo11090565 (preprint 10/26/2020) (Peer Reviewed)
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Retrospective 120 hospitalized patients in Spain showing zinc deficiency associated with higher ICU admission.
risk of mechanical ventilation, 49.3% lower, RR 0.51, p = 0.06, high zinc levels 7 of 31 (22.6%), low zinc levels 49 of 89 (55.1%), NNT 3.1, adjusted per study, odds ratio converted to relative risk, ≥84 mcg/dL, multivariate logistic regression.
risk of ICU admission, 52.0% lower, RR 0.48, p = 0.02, high zinc levels 9 of 31 (29.0%), low zinc levels 55 of 89 (61.8%), NNT 3.1, adjusted per study, odds ratio converted to relative risk, ≥84 mcg/dL, multivariate logistic regression, final model.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Tomasa-Irriguible et al., 10/26/2020, retrospective, Spain, Europe, peer-reviewed, 7 authors.
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