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0 0.5 1 1.5 2+ Hospitalization -44% Improvement Relative Risk Recovery time 12% primary c19zinc.com Thomas et al. NCT04342728 Zinc RCT EARLY TREATMENT Favors zinc Favors control
Thomas, 108 patient zinc early treatment RCT: 44% higher hospitalization [p=0.72] and 12% faster recovery [p=0.38] https://c19p.org/thomas
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Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial
Thomas et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.0369
12 Feb 2021    Source   PDF   Share   Tweet
Small 214 low-risk outpatient RCT showing non-statistically significant faster recovery with zinc and with vitamin C. Study performed in the USA where zinc deficiency is relatively uncommon. The zinc dosage is relatively low, 50mg zinc gluconate (7mg elemental zinc), one tenth of that shown to reduce the duration of colds in other studies [patrickholford.com]. NCT04342728.
risk of hospitalization, 43.7% higher, RR 1.44, p = 0.72, treatment 5 of 58 (8.6%), control 3 of 50 (6.0%).
recovery time, 11.9% lower, relative time 0.88, p = 0.38, treatment mean 5.9 (±4.9) n=58, control mean 6.7 (±4.4) n=50, mean time to a 50% reduction in symptoms, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Thomas et al., 2/12/2021, Randomized Controlled Trial, USA, North America, peer-reviewed, 11 authors, trial NCT04342728.
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