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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 43% Improvement Relative Risk Zinc  Tabatabaeizadeh et al.  META ANALYSIS c19early.org Favors zinc Favors control

Zinc supplementation and COVID-19 mortality: a meta-analysis

Tabatabaeizadeh, S., European Journal of Medical Research, doi:10.1186/s40001-022-00694-z
May 2022  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Meta analysis of five zinc treatment studies for COVID-19, showing significantly lower mortality.
6 meta analyses show significant improvements with zinc for mortality Abuhelwa, Olczak-Pruc, Rheingold, Tabatabaeizadeh, Xie, severity Fan, and cases Fan.
Currently there are 44 zinc treatment for COVID-19 studies, showing 29% lower mortality [10‑44%], 44% lower ventilation [4‑68%], 26% lower ICU admission [-7‑49%], 20% lower hospitalization [4‑34%], and 22% fewer cases [-10‑45%].
risk of death, 43.0% lower, OR 0.57, p < 0.001, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tabatabaeizadeh et al., 23 May 2022, peer-reviewed, 1 author. Contact: tabatabaei.amir@yahoo.com (corresponding author).
This PaperZincAll
Zinc supplementation and COVID-19 mortality: a meta-analysis
Seyed-Amir Tabatabaeizadeh
European Journal of Medical Research, doi:10.1186/s40001-022-00694-z
Background and aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a pneumonia outbreak and was called 2019 novel coronavirus disease . COVID-19 emerged in December 2019 and now considered a pandemic. Zinc supplementation can reduce mortality in patients with severe pneumonia. This study aimed at meta-analysis of the results of related studies and evaluate the effect of zinc supplementation on COVID-19 mortality. Methods: A systematic search has conducted for manuscripts through PUBMED/Medline and Google Scholar (Cochrane guideline has considered it as the gray literature) up to September 2021. This meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Guideline for evaluation of the effect zinc supplementation on COVID-19 mortality. Based on the heterogeneity a fixed-effect or random-effect model, the OR and 95% CI were used to assess the combined risk. Results: After assessment, five studies with 1506 participants in case and control groups were included in meta-analysis. The OR for one study was not estimable, and the pool OR was estimated for other studies with 1398 participants. The meta-analysis showed that zinc supplementation in cases led to a significant lower risk of mortality when it was compared with the control group; pooled OR (95% CI) was 0.57 [0.43, 0.77] (P < 0.001). Conclusion: This meta-analysis has suggested that zinc supplementation is associated with a lower mortality rate in COVID-19 patients. Zinc supplementation could be considered as a simple way and cost benefit approach for reduction of mortality in COVID-19 patients.
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