COVID-19 prophylaxis with doxycycline and zinc in health care workers: a prospective, randomized, double-blind clinical trial
Nejla Stambouli, Adel Driss, Faten Gargouri, Khadija Bahrini, Bilel Arfaoui, Rim Abid, Karima Taamallah, Souha Hannachi, Sana Boughariou, Aicha Rebai, Imen Naas, Mohamed Ghanem, Hassib Ammar, Chiraz Aichaouia, Asma Harrathi, Mohamed Ali Yousfi, Riadh Battikh, Mohamed Ben Moussa, Rabie Razgallah, Mustapha Ferjani, Hédi Gharsallah
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.06.016
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of interest statement: The manuscript is an original work that has never been published or is under consideration for publication in another journal. We confirm that all authors have participated in the study and have approved the manuscript.
Contributions
Declaration of interests ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:
References
Ajili, Battikh, Laabidi, Abid, Bousetta et al., Malaria in tunisian military personnel after returning from external operation, Malar Res Treat,
doi:10.1155/2013/359192Anwar, El-Dien Anwer, Abdallah, Zuk, Dechtman et al., Doxycycline: a new treatment option for COVID-19, Alexandria Journal of Medicine,
doi:10.1080/20905068.2020Castro, Kandasamy, Youssef, Schulz, Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases, Pharmacol Res,
doi:10.1016/j.phrs.2011.05.005Christopher, Yu, Dorward, Gbinigie, Hayward et al., Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial, Lancet Respir Med,
doi:10.1016/S2213-2600(21)00310-6Christopher, Yu, Dorward, Gbinigie, Hayward et al., Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial, Lancet Respir Med,
doi:10.1016/S2213-2600(21)00310-6Doroszko, Hurst, Polewicz, Sawicka, Fert-Bober et al., Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury, Proteome Sci,
doi:10.1186/1477-5956-8-3Dutta, Basu, Use of minocycline in viral infections, Indian J Med Res
Fawad, Shadan, Rowaiee, Ghanem, Khamis et al., COVID-19 and healthcare workers: A systematic review and meta-analysis, International Journal of Infectious Diseases,
doi:10.1016/j.ijid.2021.01.013Gendrot, Andreani, Jardot, Hutter, Delandre et al., COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes, American Journal of Epidemiology,
doi:10.3390/molecules25215064Griffin, Fricovsky, Ceballos, Villarreal, Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature, American Journal of Physiology-Cell Physiology,
doi:10.1152/ajpcell.00047.2010Guo, Carroll, Macdonald, Goff, Gao et al., PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship: a retrospective sentinel network cohort study, Pan Afr Med J,
doi:10.1128/JVI.78.23.12781-12787Moran, Beavis, Matushek, Ciaglia, Francois et al., Detection of SARS-CoV-2 by Use of the Cepheid Xpert Xpress SARS-CoV-2 and Roche cobas SARS-CoV-2 Assays, Journal of Clinical Microbiology n,
doi:10.1128/JCM.00772-20Platten, Hoffmann, Grosser, Wisplinghoff, Wisplinghoff et al., SARS-CoV-2, CT-Values, and Infectivity-Conclusions to Be Drawn from Side Observations, Viruses,
doi:10.3390/v13081459Ratia, Saikatendu, Santarsiero, Barretto, Baker et al., Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme, Proc Natl Acad Sci,
doi:10.3892/ijmm.2020.4575Sodhi, Etminan, Therapeutic Potential for Tetracyclines in the Treatment of COVID-19, Pharmacotherapy,
doi:10.1002/phar.2395Tan, Magill, Parise, Arguin, Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis, Am J Trop Med Hyg,
doi:10.4269/ajtmh.2011.10-0285Velthuis, Van Den Worm, She, Sims, Baric et al., Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture, PLoS Pathog,
doi:10.1371/journal.ppat.1001176Wessels, Rolles, Rink, Yates, Pa et al., Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease, Frontiers in Immunology,
doi:10.3389/fimmu.2020.01712
