Stambouli, 115 patient zinc prophylaxis RCT: 68% fewer symptomatic cases [p=0.36], 5% fewer cases [p=1], and 21% improved viral load [p<0.0001] https://c19p.org/stambouli
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COVID-19 prophylaxis with Doxycycline and Zinc in Health Care Workers: A prospective randomized double-blind clinical tria
et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.06.016, NCT04584567 (history)
Prophylaxis RCT with 59 zinc + doxycycline, 56 doxycycline, and 57 placebo healthcare workers, showing lower symptomatic cases and significantly improved Ct values with the addition of zinc to doxycycline treatment. Doxycycline 100mg/day and zinc 15 mg/day.
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risk of symptomatic case, 68.4% lower, RR 0.32, p = 0.36, treatment 1 of 59 (1.7%), control 3 of 56 (5.4%), NNT 27, zinc + doxycycline vs. doxycycline.
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risk of case, 5.1% lower, RR 0.95, p = 1.00, treatment 5 of 59 (8.5%), control 5 of 56 (8.9%), NNT 220, zinc + doxycycline vs. doxycycline.
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relative Ct values, 21.4% better, RR 0.79, p < 0.001, treatment mean 29.0 (±1.3) n=59, control mean 22.8 (±4.0) n=56, zinc + doxycycline vs. doxycycline.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Stambouli et al., 17 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, peer-reviewed, 22 authors, study period 12 November, 2020 - 10 February, 2021, trial NCT04584567 (history).
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