and In Vitro
study showing that ionic zinc inhibits SARS-CoV-2 main protease (Mpro
) and inhibits viral replication.
Zinc acetate inhibited viral replication in Vero E6 cells, while zinc glycinate and zinc gluconate did not at non-toxic concentrations. The combination of zinc acetate with zinc ionophore quercetin significantly improved inhibition at low concentrations.
Panchariya et al., 6/15/2021, peer-reviewed, 18 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.