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15 June 2021 - In Vitro
Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro
Panchariya et al., Chemical Communications, doi:10.1039/D1CC03563K (Peer Reviewed) (In Vitro)
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In Silico and In Vitro study showing that ionic zinc inhibits SARS-CoV-2 main protease (Mpro) and inhibits viral replication.
Zinc acetate inhibited viral replication in Vero E6 cells, while zinc glycinate and zinc gluconate did not at non-toxic concentrations. The combination of zinc acetate with zinc ionophore quercetin significantly improved inhibition at low concentrations.
Panchariya et al., 6/15/2021, peer-reviewed, 18 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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