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0 0.5 1 1.5 2+ Mortality 53% Improvement Relative Risk Ventilation 64% ICU admission 60% Death/ventilation/ICU 58% primary Progression to ARDS 85% c19zinc.com Mayberry et al. Zinc for COVID-19 EARLY TREATMENT Favors zinc Favors control
Mayberry, 2,028 patient zinc early treatment study: 53% lower mortality [p<0.0001], 64% lower ventilation [p<0.0001], 60% lower ICU admission [p<0.0001], and 58% lower combined mortality/ICU admission [p<0.0001] https://c19p.org/mayberry
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Zinc use is associated with improved outcomes in COVID-19: results from the CRUSH-COVID registry
Mayberry et al., Critical Care Medicine, doi:10.1097/01.ccm.0000807104.82650.d6
16 Dec 2021    Source   PDF   Share   Tweet
Retrospective 2,028 COVID patients in the USA, showing significantly lower mortality, ventilation, ICU admission, and progression to ARDS with zinc use, defined as at least one dose from one week prior to admission to 48 hours after admission.
risk of death, 53.5% lower, OR 0.47, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
risk of mechanical ventilation, 64.2% lower, OR 0.36, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
risk of ICU admission, 60.0% lower, OR 0.40, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
death/ventilation/ICU, 57.8% lower, OR 0.42, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, primary outcome, RR approximated with OR.
progression to ARDS, 85.4% lower, OR 0.15, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mayberry et al., 16 Dec 2021, retrospective, USA, peer-reviewed, 14 authors, study period March 2020 - April 2021.
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