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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 90% Improvement Relative Risk ICU admission 92% c19zinc.com/jothimani.html Favors zinc Favors control
10 September 2020 - Analysis of outcomes based on serum levels
COVID-19: Poor outcomes in patients with zinc deficiency
Jothimani (Peer Reviewed)
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Prospective study of zinc levels in 47 hospitalized COVID-19 patients and 45 healthy controls. COVID-19 patients had significantly lower zinc levels (74.5 vs. 105.8 median μg/dl, p < 0.001). 57.4% of COVID-19 patients were zinc deficient, and they had higher rates of complications, ARDS, prolonged hospital stay, and increased mortality.
risk of death, 89.7% lower, RR 0.10, p = 0.06, high zinc levels 0 of 20 (0.0%), low zinc levels 5 of 27 (18.5%), NNT 5.4, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 92.4% lower, RR 0.08, p = 0.02, high zinc levels 0 of 20 (0.0%), low zinc levels 7 of 27 (25.9%), NNT 3.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Jothimani et al., 9/10/2020, prospective, India, South Asia, peer-reviewed, 11 authors.
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