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Bamlanivimab Nigella Sativa
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Zinc study #6 of 37   All Outcomes
9/10 Analysis of outcomes based on serum levels
Jothimani (Peer Reviewed)
COVID-19: Poor outcomes in patients with zinc deficiency
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Prospective study of zinc levels in 47 hospitalized COVID-19 patients and 45 healthy controls. COVID-19 patients had significantly lower zinc levels (74.5 vs. 105.8 median μg/dl, p < 0.001). 57.4% of COVID-19 patients were zinc deficient, and they had higher rates of complications, ARDS, prolonged hospital stay, and increased mortality.
Jothimani et al., 9/10/2020, prospective, India, South Asia, peer-reviewed, 11 authors.
risk of death, 89.7% lower, RR 0.10, p = 0.06, high zinc levels 0 of 20 (0.0%), low zinc levels 5 of 27 (18.5%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 92.4% lower, RR 0.08, p = 0.02, high zinc levels 0 of 20 (0.0%), low zinc levels 7 of 27 (25.9%), continuity correction due to zero event (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 37 studies   All Outcomes
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