Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population
et al., Epidemiology and Global Health Microbiology and Infectious Disease,
Case control study examining medication usage with a healthcare database in Israel, showing lower risk of hospitalization with calcium + zinc supplements (defined as being picked up within 35 days prior to PCR+), however only 10 patients took the supplements. Other patients may have acquired supplements outside of the healthcare system.
risk of hospitalization, >99.99% lower, OR <0.001, p = 0.04, treatment 0 of 6,953 (0.0%) cases,
10 of 13,906 (0.1%) controls, NNT 3.0, case control OR, PCR+, cohort 2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta
treatment or control group size extremely small.
Israel et al., 7/27/2021, retrospective, Israel, Middle East, peer-reviewed, 10 authors, this trial uses multiple treatments in the treatment arm (combined with calcium) - results of individual treatments may vary.