13 December 2021 - Prophylaxis study
A Case-Control Study for the Effectiveness of Oral Zinc in the Prevention and Mitigation of COVID-19
et al., Frontiers in Medicine, doi:10.3389/fmed.2021.756707 (Peer Reviewed)
Prospective study of zinc supplementation with 104 patients randomized to receive 10mg, 25mg, or 50mg of zinc picolinate daily, and a matched sample of 96 control patients from the adjacent clinic that did not routinely recommend/use zinc, showing significantly lower symptomatic COVID-19 with treatment.
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risk of death, 67.6% lower, RR 0.32, p = 0.48, treatment 0 of 104 (0.0%), control 1 of 96 (1.0%), NNT 96, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of symptomatic case, 85.3% lower, RR 0.15, p = 0.02, treatment 2 of 104 (1.9%), control 9 of 96 (9.4%), NNT 13, adjusted per study, odds ratio converted to relative risk.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
Gordon et al., 12/13/2021, prospective, USA, North America, peer-reviewed, 2 authors.
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