Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS-CoV-2

12/23 Analysis of outcomes based on serum levels

Gonçalves et al., Nutrition in Clinical Practice, doi:10.1002/ncp.10612 (Peer Reviewed)
Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus SARS-CoV-2

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Retrospective 169 ICU patients in Brazil, 214 with low zinc levels, showing an association between low zinc levels and severe ARDS. CAAE 30608,020.9.0000.8114.

Gonçalves et al., 12/23/2020, retrospective, Brazil, South America, peer-reviewed, 9 authors.

risk of COVID-19 severe case, 82.3% lower, RR 0.18, p < 0.001, treatment 7 of 55 (12.7%), control 145 of 214 (67.8%), adjusted per study, odds ratio converted to relative risk, ≥70 μg/dL, logistic regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 31 studies All Outcomes

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