5/3 Analysis of outcomes based on serum levels
et al., Clinical Nutrition, doi:10.1016/j.clnu.2021.04.042 (Peer Reviewed)
Hypozincemia in the early stage of COVID-19 is associated with an increased risk of severe COVID-19
Hypozincemia in the early stage of COVID-19 is associated with an increased risk of severe COVID-19
Analysis of 240 consecutive patients in France, showing significantly higher zinc deficiency in COVID-19 patients, and significantly greater risk of hospitalization for COVID-19 patients with zinc deficiency. 2020PI087.
Fromonot et al., 5/3/2021, prospective, France, Europe, peer-reviewed, 6 authors.
risk of hospitalization, 89.2% lower, RR 0.11, p = 0.002, high zinc levels 6 of 110 (5.5%), low zinc levels 7 of 42 (16.7%), odds ratio converted to relative risk, within COVID-19 patients.
risk of COVID-19 case, 27.6% lower, RR 0.72, p = 0.003, high zinc levels 110 of 188 (58.5%), low zinc levels 42 of 52 (80.8%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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