Hypozincemia in the early stage of COVID-19 is associated with an increased risk of severe COVID-19

5/3 Analysis of outcomes based on serum levels

Fromonot et al., Clinical Nutrition, doi:10.1016/j.clnu.2021.04.042 (Peer Reviewed)
Hypozincemia in the early stage of COVID-19 is associated with an increased risk of severe COVID-19

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Analysis of 240 consecutive patients in France, showing significantly higher zinc deficiency in COVID-19 patients, and significantly greater risk of hospitalization for COVID-19 patients with zinc deficiency. 2020PI087.

Fromonot et al., 5/3/2021, prospective, France, Europe, peer-reviewed, 6 authors.

risk of hospitalization, 89.2% lower, RR 0.11, p = 0.002, treatment 6 of 110 (5.5%), control 7 of 42 (16.7%), odds ratio converted to relative risk, within COVID-19 patients.

risk of COVID-19 case, 27.6% lower, RR 0.72, p = 0.003, treatment 110 of 188 (58.5%), control 42 of 52 (80.8%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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