Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients

5/8 Late treatment study

Carlucci et al., J. Med. Microbiol., Sep 15, 2020, doi: 10.1099/jmm.0.001250 (preprint 5/8) (Peer Reviewed)
Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients

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Retrospective 932 patients showing that the addition of zinc to HCQ+AZ reduced mortality / transfer to hospice, ICU admission, and the need for ventilation.

Carlucci et al., 5/8/2020, retrospective, USA, North America, peer-reviewed, 6 authors.

risk of combined death/hospice, 37.7% lower, RR 0.62, p = 0.002, treatment 54 of 411 (13.1%), control 119 of 521 (22.8%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression.

risk of mechanical ventilation, 18.0% lower, RR 0.82, p = 0.40, treatment 29 of 411 (7.1%), control 62 of 521 (11.9%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression.

risk of ICU admission, 23.5% lower, RR 0.77, p = 0.17, treatment 38 of 411 (9.2%), control 82 of 521 (15.7%), adjusted per study, odds ratio converted to relative risk, multivariate logistic regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

All 31 studies All Outcomes

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