8 May 2020 - Late treatment study
Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients
et al., J. Med. Microbiol., Sep 15, 2020, doi: 10.1099/jmm.0.001250 (preprint 5/8) (Peer Reviewed)
Retrospective 932 patients showing that the addition of zinc to HCQ+AZ reduced mortality / transfer to hospice, ICU admission, and the need for ventilation.
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risk of death/hospice, 37.7% lower, RR 0.62, p = 0.002, treatment 54 of 411 (13.1%), control 119 of 521 (22.8%), NNT 10, adjusted per study, odds ratio converted to relative risk, multivariate logistic regression.
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risk of mechanical ventilation, 18.0% lower, RR 0.82, p = 0.40, treatment 29 of 411 (7.1%), control 62 of 521 (11.9%), NNT 21, adjusted per study, odds ratio converted to relative risk, multivariate logistic regression.
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risk of ICU admission, 23.5% lower, RR 0.77, p = 0.17, treatment 38 of 411 (9.2%), control 82 of 521 (15.7%), NNT 15, adjusted per study, odds ratio converted to relative risk, multivariate logistic regression.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
Carlucci et al., 5/8/2020, retrospective, USA, North America, peer-reviewed, 6 authors.
carlucci
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