Retrospective 932 patients. Addition of Zinc to HCQ+AZ reduces mortality / transfer to hospice, ICU admission, and the need for ventilation.
Reduction in mortality or transfer to hospice adjusted odds ratio OR 0.56,
p = 0.002; increase in being discharged home, adjusted OR 1.53,
p = 0.008.
Carlucci et al., 5/8/2020, retrospective, peer-reviewed, 6 authors.
risk of combined death/hospice, 37.8% lower, RR 0.62, p = 0.002, treatment 411, control 521, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious
outcomes. For an individual study the most serious outcome may have a smaller
number of events and lower statistical signficance, however this provides the
strongest evidence for the most serious outcomes when combining the results of
many trials.