Zinc and Vitamin A Deficiency Predisposes to the Need for Intubation and ICU Admission in Patients With COVID-19. An Observational Study

10/26 Analysis of outcomes based on serum levels

Berrocal et al., Research Square, doi:10.21203/rs.3.rs-95524/v1 (Preprint)
Zinc and Vitamin A Deficiency Predisposes to the Need for Intubation and ICU Admission in Patients With COVID-19. An Observational Study

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Retrospective 120 hospitalized patients showing zinc deficiency associated with higher ICU admission.

Berrocal et al., 10/26/2020, retrospective, Spain, Europe, preprint, 7 authors.

risk of death, 44.8% lower, RR 0.55, p = 0.23, treatment 5 of 31 (16.1%), control 26 of 89 (29.2%), ≥84 mcg/dL.

risk of ICU admission, 53.0% lower, RR 0.47, p = 0.003, treatment 9 of 31 (29.0%), control 55 of 89 (61.8%), ≥84 mcg/dL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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