Retrospective 266 ICU patients showing lower mortality with zinc treatment (very close to statistical significance), and higher odds of acute kidney injury.
Al Sulaiman et al., 6/7/2021, retrospective, Saudi Arabia, Middle East, preprint, 10 authors.
risk of death, 35.0% lower, RR 0.65, p = 0.05, treatment 35 of 130 (26.9%), control 45 of 129 (34.9%), adjusted per study, 30 day, PSM, multivariable Cox proportional hazards.
risk of mechanical ventilation, 23.0% lower, RR 0.77, p = 0.52, treatment 20 of 57 (35.1%), control 23 of 54 (42.6%), adjusted per study, among non-mechanically ventilated patients within 24 hours of ICU admission.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.