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0 0.5 1 1.5 2+ Mortality 36% Improvement Relative Risk Mortality (b) 48% ICU time -25% Hospitalization time -6% c19zinc.com Al Sulaiman et al. Zinc for COVID-19 ICU PATIENTS Favors zinc Favors control
Al Sulaiman, 164 patient zinc ICU PSM study: 36% lower mortality [p=0.11], 25% higher ICU admission [p=0.28], and 6% longer hospitalization [p=0.61] https://c19p.org/alsulaiman
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Evaluation of Zinc Sulfate as an Adjunctive Therapy in COVID-19 Critically Ill Patients: a Two Center Propensity-score Matched Study
Al Sulaiman et al., Critical Care, doi:10.1186/s13054-021-03785-1 (preprint 6/7/2021)
7 Jun 2021    Source   PDF   Share   Tweet
Retrospective 266 ICU patients showing lower mortality with zinc treatment (very close to statistical significance), and higher odds of acute kidney injury. NRC21R/287/07.
risk of death, 36.0% lower, HR 0.64, p = 0.11, treatment 23 of 82 (28.0%), control 32 of 82 (39.0%), NNT 9.1, adjusted per study, in-hospital, PSM, multivariable Cox proportional hazards.
risk of death, 48.0% lower, HR 0.52, p = 0.03, treatment 19 of 82 (23.2%), control 31 of 82 (37.8%), NNT 6.8, adjusted per study, 30 day, PSM, multivariable Cox proportional hazards.
ICU time, 25.0% higher, relative time 1.25, p = 0.28, treatment 82, control 82.
hospitalization time, 6.2% higher, relative time 1.06, p = 0.61, treatment 82, control 82.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al Sulaiman et al., 6/7/2021, retrospective, propensity score matching, Saudi Arabia, Middle East, peer-reviewed, 10 authors, study period 1 March, 2020 - 31 March, 2021.
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