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Zinc study #19 of 22   All Outcomes
6/7 Late treatment study
Al Sulaiman et al., Research Square, doi:10.21203/rs.3.rs-572942/v1 (Preprint)
Evaluation of Zinc Sulfate as an Adjunctive Therapy in COVID-19 Critically Ill Patients: a Two Center Propensity-score Matched Study
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Retrospective 266 ICU patients showing lower mortality with zinc treatment (very close to statistical significance), and higher odds of acute kidney injury.

Al Sulaiman et al., 6/7/2021, retrospective, Saudi Arabia, Middle East, preprint, 10 authors.
risk of death, 35.0% lower, RR 0.65, p = 0.05, treatment 35 of 130 (26.9%), control 45 of 129 (34.9%), adjusted per study, 30 day, PSM, multivariable Cox proportional hazards.
risk of mechanical ventilation, 23.0% lower, RR 0.77, p = 0.52, treatment 20 of 57 (35.1%), control 23 of 54 (42.6%), adjusted per study, among non-mechanically ventilated patients within 24 hours of ICU admission.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 22 studies   All Outcomes
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