Retrospective 266 ICU patients showing lower mortality with zinc treatment (very close to statistical significance), and higher odds of acute kidney injury. NRC21R/287/07.
Al Sulaiman et al., 6/7/2021, retrospective, propensity score matching, Saudi Arabia, Middle East, peer-reviewed, 10 authors.
risk of death, 36.0% lower, RR 0.64, p = 0.11, treatment 23 of 82 (28.0%), control 32 of 82 (39.0%), adjusted per study, in-hospital, PSM, multivariable Cox proportional hazards.
risk of death, 48.0% lower, RR 0.52, p = 0.03, treatment 19 of 82 (23.2%), control 31 of 82 (37.8%), adjusted per study, 30 day, PSM, multivariable Cox proportional hazards.
ICU time, 25.0% higher, relative time 1.25, p = 0.28, treatment 82, control 82.
hospitalization time, 6.2% higher, relative time 1.06, p = 0.61, treatment 82, control 82.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.