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Zinc study #12 of 15
11/29 Late treatment study
Abd-Elsalam et al., Biological Trace Element Research, doi:10.1007/s12011-020-02512-1 (Peer Reviewed)
Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial
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191 patient RCT in Egypt comparing the addition of zinc to HCQ, not showing a significant difference.
Clinical recovery at 28 days was 79.2% in the zinc group and 77.9% control, p = 0.969.
Mechanical ventilation was used with 4 patients in the zinc group and 6 control. There were 5 deaths in each group.
No information on baseline zinc values was recorded. We note that Egypt has a low rate of zinc deficiency so supplementation is less likely to be helpful in Egypt [1, 2]

Abd-Elsalam et al., 11/29/2020, Randomized Controlled Trial, Egypt, Middle East, peer-reviewed, 10 authors.
risk of death, 1.0% lower, RR 0.99, p = 0.99, treatment 5 of 96 (5.2%), control 5 of 95 (5.3%).
risk of mechanical ventilation, 34.0% lower, RR 0.66, p = 0.54, treatment 4 of 96 (4.2%), control 6 of 95 (6.3%).
risk of no recovery, 5.8% lower, RR 0.94, p = 0.97, treatment 20 of 96 (20.8%), control 21 of 95 (22.1%).
hospitalization time, 3.6% lower, relative time 0.96, p = 0.55, treatment 96, control 95.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 15 studies
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